Detailed view for CT_379

Basic information

TDR Targets ID: 934677
Chlamydia trachomatis, GTPase HflX
Source Database / ID:  KEGG  

pI: 7.0622 | Length (AA): 447 | MW (Da): 50913 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01926   50S ribosome-binding GTPase
PF13167   GTP-binding GTPase N-terminal
PF16360   GTP-binding GTPase Middle Region

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
42 223 5haz (A) 1051 1241 15.00 0 0.58 0.506359 -0.11
49 391 2qtf (A) 11 354 32.00 0 1 0.942538 -0.19
222 394 1wf3 (A) 3 176 22.00 0 0.96 0.727225 -0.77
228 398 4awx (A) 5 182 36.00 0.0021 0.48 0.55605 0.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128084)

Species Accession Gene Product
Arabidopsis thaliana AT5G57960   GTP-binding protein, HflX
Arabidopsis thaliana AT3G49725   GTP-binding protein, HflX
Brugia malayi Bm1_12380   MGC83645 protein
Caenorhabditis elegans CELE_F46B6.4   Protein F46B6.4
Chlamydia trachomatis CT_379   GTPase HflX
Drosophila melanogaster Dmel_CG5116   CG5116 gene product from transcript CG5116-RB
Escherichia coli b4173   GTPase, stimulated by 50S subunit binding
Echinococcus granulosus EgrG_000853800   GTP binding protein hflx
Echinococcus multilocularis EmuJ_000853800   GTP binding protein hflx
Homo sapiens ENSG00000178605   GTP binding protein 6 (putative)
Loa Loa (eye worm) LOAG_03897   hypothetical protein
Mycobacterium leprae ML0997   PROBABLE GTP-BINDING PROTEIN HFLX
Mus musculus ENSMUSG00000033434   GTP binding protein 6 (putative)
Mycobacterium tuberculosis Rv2725c   Probable GTP-binding protein HflX
Mycobacterium ulcerans MUL_3368   GTP-binding protein HflX
Neospora caninum NCLIV_029330   hypothetical protein
Oryza sativa 4350828   Os11g0592700
Oryza sativa 4333978   Os03g0727900
Onchocerca volvulus OVOC13458  
Plasmodium berghei PBANKA_0934100   GTP-binding protein, putative
Plasmodium falciparum PF3D7_1113500   GTP-binding protein, putative
Plasmodium knowlesi PKNH_0911100   GTP-binding protein, putative
Plasmodium vivax PVX_091320   hypothetical protein, conserved
Plasmodium yoelii PY00735   Y14391 GTP-binding protein
Schistosoma japonicum Sjp_0038540   ko:K03665 GTP-binding protein HflX, putative
Schistosoma mansoni Smp_016550.1   GTP-binding protein hflx
Schistosoma mansoni Smp_016550.2   GTP-binding protein hflx
Schmidtea mediterranea mk4.047236.00  
Schmidtea mediterranea mk4.000948.03   Putative gtp-binding protein hflx
Toxoplasma gondii TGME49_255470   hypothetical protein
Trichomonas vaginalis TVAG_143480   Rab6, putative

Essentiality

CT_379 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2771 Mycobacterium tuberculosis non-essential nmpdr
b4173 Escherichia coli non-essential goodall
PBANKA_0934100 Plasmodium berghei Essential plasmo
TGME49_255470 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier CT_379 (Chlamydia trachomatis), GTPase HflX
Title for this comment
Comment